Keywords
THROMBOSIS
VACCINE
How to Cite
Abstract
Recientemente ha surgido una controversia en la población sobre el riesgo de trombosis de la vacuna para el coronavirus SARS-CoV-2 y muchos pacientes nos consultan sobre el riesgo de que una complicación trombótica fatal ocurra luego de vacunarse.
Esto se ha visto potenciado por la difusión en los medios de comunicación que resaltan noticias surgidas desde Europa y EEUU en el último mes sobre la suspensión por la Agencia Europea de Medicamentos (EMA) de la vacunación a causa de un raro fenómeno de plaquetopenia y trombosis en sitios inusuales, con una mortalidad de hasta 20-40%(1).
Sobre este raro evento adverso de la vacuna creo que debemos aclarar algunos conceptos importantes para informar correctamente a nuestros pacientes.
References
2. Voysey M, Clemens SAC, Madhi SA, Oxford COVID Vaccine Trial Group. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARSCoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet. 2021 Jan 9;397(10269):99-11.1
3. Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination. N Engl J Med. 2021 Apr 9. doi: 10.1056/NEJMoa2104840. Epub ahead of print. PMID: 33835769.
4. U.S. Food & Drugs Administration. Joint CDC and FDA Statement on Johnson & Johnson COVID-19 Vaccine. 13/04/2021. Disponible en: https://www.fda.gov/news-events/press-announcements/joint-cdcandfda-statement-johnson-johnson-covid-19-vaccine 5. Ishac Nazy, Ulrich J Sachs, Donald M. Arnold y col. Recommendations for the clinical and laboratory diagnosis of vaccine-induced immune thrombotic thrombocytopenia (VITT) for SARS-CoV-2 infections: Communication from the ISTH SSC Subcommittee on Platelet Immunology. doi: 10.1111/JTH.15341
6. Oldenburg J, Klamroth R, Langer F, Greinacher A. Diagnosis and Management of Vaccine-Related Thrombosis
following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH. Hamostaseologie.
2021 Apr 1. doi: 10.1055/a-1469-7481. Epub ahead of print. PMID: 33822348.
7. von Hundelshausen P, Lorenz R, Siess W, Weber C. Vaccine-induced immune thrombotic thrombocytopenia (VITT): targeting pathomechanisms with Bruton tyrosine kinase inhibitors. Thromb Haemost. 2021 Apr 13. doi: 10.1055/a-1481-3039. Epub ahead of print. PMID: 33851389.
8. Informe especial de la Comisión Nacional de Seguridad en Vacunas (CoNaSeVa), Abril 2021. Recomendaciones para el diagnóstico y manejo del síndrome trombótico post administración de vacunas contra la COVID-19.
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