Abstract
DOAC represent an evolution for oral anticoagulation in the prevention of venous thromboembolism in major orthopaedic surgery of the limbs, the treatment of the different phases of deep vein thrombosis and pulmonary embolism and the stroke prevention in non-valvular atrial fibrillation. This paper is aimed to dissect the different aspects to consider at the election of the antithrombotic agents, according to several clinical and socio-economical aspects leading to a better individualization of the treatment, and to provide useful resources for the practicing physician and his patients.
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