Keywords
NK cells
STAT3
How to Cite
Abstract
Large granular lymphocyte leukemia is a rare disorder characterized by the clonal expansion of lymphocytes with a T cell phenotype (CD3+) in approximately 85%, while the remainder corresponds to NK cells (CD3-). Although its etiology is unknown, it has been related to chronic antigenic stimulation. Clinical presentation may include neutropenia, anemia, splenomegaly and recurrent infections. The diagnosis is based on the identification of clonal atypical large granular lymphocytes in the blood with the exclusion of reactive expansions and an in the context of a suitable clinical presentation. Immunosuppression is the first-line therapy, correcting cytopenias in about half of the patients. We present the case of a 77-year-old male patient, with no relevant personal history, diagnosed with large granular lymphocyte leukemia with NK immunophenotype and mutation in the STAT3 gene, who began treatment with immunosuppressants and supportive therapy due to cytopenias.
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