Hemophagocytic syndrome secondary to diffuse large B-cell primary lymphoma of the spleen: first case reported in Ecuador.

Abstract

Hemophagocytic syndrome represents a hyperinflammatory and potentially fatal medical emergency, with high mortality rates ranging from 60% to 80%. In cases associated with hematologic malignancies or severe infections, the prognosis can be even more discouraging if immediate treatment is not initiated. We present the case of a 66-year-old male patient with hemophagocytic syndrome secondary to diffuse large B-cell lymphoma and Epstein-Barr virus infection, treated with corticosteroids and etoposide. After a relapse, he underwent a splenectomy with clinical improvement.