Ischemic stroke secondary to antithrombin III deficiency: a case report
Revista Hematología
pdf (Español (España))
html (Español (España))

Keywords

Encephalopathy, Antithrombin, ACV

How to Cite

Wilches Meza , A., Navarro, J., Martínez Guerrero, G., García Osorio, A., Arenas López, K., Gonzalez Torres, E., & Chaytili Gomez, K. (2025). Ischemic stroke secondary to antithrombin III deficiency: a case report. Journal of Hematology, 29(1), 78–83. https://doi.org/10.48057/hematologa.v29i1.618

Abstract

This is the case of a 25-year-old patient with an atypical ischemic cerebrovascular accident (CVA) and no classical risk factors. The patient was admitted due to severe headache, which progressed to cardiorespiratory arrest. A brain CT scan revealed multiple ischemic areas in the cerebellum and the right occipitotemporal region, not attributable to post-CPR hypoperfusion. MRI showed extensive acute ischemic lesions with hemorrhagic transformation in the bilateral parieto-occipital lobes, right temporal lobe, cerebellar hemispheres, brainstem, and other Deep regions. Studies confirmed severe antithrombin III (AT) deficiency as the only identifiable cause. This protein plays a key role in coagulation regulation, and its deficiency leads to hypercoagulability. This case underscores the importance of investigating coagulation disorders in young patients with thrombosis and highlights the need for early diagnosis and multidisciplinary management.

https://doi.org/10.48057/hematologa.v29i1.618
pdf (Español (España))
html (Español (España))

References

García C, Martínez A, Garcia V, Ricaurte-Fajardo A, Torres I, Coral J. Actualización en diagnóstico y tratamiento del ataque cerebrovascular isquémico agudo. Univ Med. 2019;60(3). Disponible en: https://revistas.javeriana.edu.co/files-articulos/UMED/60-3%20(2019-III)/231059231008/

Jiménez R. Antitrombina III en estados normales y patológicos. Rev Costarric Cienc Méd. 1983;4(2):39-54. Disponible en: https://www.binasss.sa.cr/revistas/rccm/v4n2/art6.pdf

Franco-Díaz de León R; Gamboa-Solís R; Sánchez-Díaz de León JA et al. Trombosis venosa profunda de miembros inferiores asociada a una triple deficiencia enzimática: antitrombina III, proteína C y proteína S. Reporte de caso. Rev Lux Medica. 2021; 16(48). Disponible en: https://doi.org/10.33064/48lm20213335

Tapia J. Enfermedad cerebrovascular y trombofilia. Rev Chil Neuro-psiquiatr. [Internet]. 2002 Abr [citado 2024 Nov 13] ; 40( 2 ): 37-45. Disponible en: http://dx.doi.org/10.4067/S0717-92272002000200004

Accidente cerebrovascular isquémico. Manual MSD, versión para profesionales. [Internet]. 2023. Disponible en: https://www.msdmanuals.com/es/professional/trastornos-neurol%C3%B3gicos/accidente-cerebrovascular/accidente-cerebrovascular-isqu%C3%A9mico

Déficit de antitrombina III. Redacción Médica. [Internet]. 2023. Disponible en: https://www.redaccionmedica.com/recursos-salud/diccionario-enfermedades/deficit-antitrombina-iii

Patnaik MM, Moll S. Hereditary thrombophilia: Clinical syndromes and management. Mayo Clin Proc. 2008;83(5):533-544.

Dahlbäck B. Advances in understanding pathogenic mechanisms of thrombophilic disorders. Blood Rev. 2008;22(3):107-116.

Nitzki-George D, Farrow JM. Hypercoagulable states and sepsis: A review of pathophysiology and treatment. Crit Care Med. 2016;44(2):314-322.

Di Nisio M, et al. Antithrombin deficiency and risk of thrombosis: A meta-analysis. Thromb Res. 2010;126(5):e337-e342.

Levine MN, Lee AY, Kakkar AK. Thrombophilia in young patients: Aetiology and management. J Thromb Haemost. 2001;90(1):20-25.

Berlot G et al. Antithrombin supplementation in sepsis: A narrative review. J Intensive Care Med. 2012;27(4):252-260.

Zaidi A, Green L. Physiology of haemostasis. Anaesth Intensive Care Med. 2019;20(3):152-158. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1472029919300050

Francisco Pérez-Gómez and Ramón Bover. The New Coagulation Cascade and Its Possible Influence on the Delicate Balance Between Thrombosis and Hemorrhage. Rev Esp Cardiol. 2007;60(12):1217-9.

Choreño-Parra JA, Carnalla-Cortés M, Guadarrama- Ortíz P. Enfermedad vascular cerebral isquémica: revisión extensa de la bibliografía para el médico de primer contacto. Med. interna Méx. [revista en la Internet]. 2019 Feb [citado 2024 Nov 16] ;35( 1 ):61-79. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0186-48662019000100061&lng=es. https://doi.org/10.24245/mim.v35i1.2212

All material published in the journal HEMATOLOGÍA (electronic and print version) is transferred to the Argentinean Society of Hematology. In accordance with the copyright Act (Act 11 723), a copyright transfer form will be sent to the authors of approved works, which has to be signed by all the authors before its publication. Authors should keep a copy of the original since the journal is not responsible for damages or losses of the material that was submitted. Authors should send an electronic version to the email: revista@sah.org.ar

Downloads

Download data is not yet available.