Abstract
We present a male patient with first diagnosis of Philadelphia chromosome negative myeloproliferative neoplasm (MPN), with no response to treatment and worsening of his symptoms. In further studies, stands out the coexisting diagnosis of chronic myeloid leukemia (CML) and afterwards the patient develops anemia requiring transfusions. The characteristics of this case represented a diagnostic and therapeutic challenge for the treating medical team and led to new re-assessments of the patient's situation, as well as consults with experts in the field in order to search for better strategies. A bibliographical review of the subject is described below.
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