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Abstract
Mantle cell lymphoma (MCL) originates from the pre-germinal B cells of the inner mantle zone of the lymphoid follicle. As an immunophenotypic characteristic, nuclear CCD-1 (cyclin D1) labeling is expressed in over 95% of the cases(1). We report a 56-year-old patient diagnosed with MCL who underwent systemic chemotherapy with complete remission and early relapse after a 7- month follow-up. The patient underwent a new biopsy and immunohistochemistry investigations, and a diagnosis of diffuse large B-cell lymphoma (DLBCL) was established. Given this scenario, the question was raised as whether an MCL progressed with DLBCL or whether the initial MCL diagnosis was confused with a DLBCL. Herein we aim to report on the clinical and histopathological manifestations of this case based on a literature review.
References
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