Keywords
basophils
hemorrhage
myeloid leukemia
How to Cite
Abstract
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML) with high complete remission and disease rates. However, early mortality rate remains the main obstacle to achieve a cure. Identify severe hemorrhage predictive factors could help to improve this situation. I, may the presence of characteristics associated basophil differentiation in leukemic promyelocytes emerge as a new predictor for severe bleeding.
References
Cicconi L, Lo-Coco F. Current management of newly diagnosed acute promyelocytic leukemia. Ann Oncol. 2016;27(8):1474-1481.
Matarraz S, Leoz P, Fernández C et al. Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy. Mod Pathol. 2018;31(8):1318-1331.
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