Keywords
Thrombocytopenia, risk factor, therapy unit.
How to Cite
Abad Zurita, T. A., Cermelj, M., & Scoles, G. (2021). Thrombocytopenia as a risk factor for morbi-mortality in hospitalized patients in one Intensive Therapy Unit. Journal of Hematology, 25(1), 9–18. Retrieved from https://revistahematologia.com.ar/index.php/Revista/article/view/361
Abstract
Alterations in the platelet count, mainly the decrease in the number of platelets called plateletpenia or thrombocytopenia, are frequently observed in patients admitted to the Intensive Care Unit. Different factors intervene in its development, the multifactorial cause being more frequent. Thrombocytopenia in patients hospitalized in Intensive Care can be a predictive factor of mortality. In the present study, the causes of thrombocytopenia in critically ill patients, the complications derived from it, and their relationship as a predictor of poor evolution are analyzed.
References
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29. Sharathkumar A, Shapiro A. Trastornos de la función plaquetaria. Tratamiento de la Hemofilia. 2008;19:1-22.
30. Thachil J, Warkentin T. How do we approach thrombocytopenia in critically ill patients? British Journal of Haematology. 2017;177(1):27-38.
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32. Wang H, Aguilera C, Knopf K y col. Thrombocytopenia in the Intensive Care Unit. J Intensive Care Med. 2013;28(5):268-280. 33. Williamson D, Albert M, Heels D. Thrombocytopenia in critically ill patients receiving thromboprophylaxis. Frequency, risk factors, and outcomes. CHEST Journal. 2013;144 (4):1207-1215.
34. Zarychanski R., Houston D. Assessing thrombocytopenia in the intensive care unit: The past, present, and future. Hematology. 2017;1:660-666.
2. Aranda F, Perés S, Larrañaga G. Inmunotrombosis: implicancias de las trampas extracelulares de neutrófilos en el desarrollo y progresión de la enfermedad tromboembólica venosa. Hematología. 2015;19(3):231-245.
3. Arepally G. Heparin induced thrombocytopenia. Blood. 2017 May 25; 129(21):2864-2872.
4. Aris M, Duboscq C, Martinuzzo M y col. Trombocitopenia inducida por heparina (HIT). Guías de diagnóstico y tratamiento. Sociedad Argentina de Hematología. 2019; 309-322.
5. Aster R, Curtis B, McFarland J y col. 2009 Drug-induced immune thrombocytopenia: pathogenesis, diagnosis and management. Journal of Thrombosis and Haemostasis. 2009; 7:911-918.
6. Bermejo E. Fisiología de la hemostasia normal. Plaqueta. Hematología. 2017;21. N° Extraordinario:10-18.
7. Bizzaro N. Pseudothrombocytopenia. Platelets, 3rd edition. 2013; Chapter 48. 989-997.
8. Cambiazzo S. Fracción de plaquetas inmaduras. Hematología. 2017;21(3):335-337.
9. Carestia A, Kaufman T y Schattner M. Rol de las plaquetas en la formación de trampas de ADN derivadas de neutrófilos. Acta Bioquímica Clínica Latinoamericana. 2016;50(2):247-54.
10. Cuker A y Neunert C. How I treat refractory immune thrombocytopenia. Blood Journal. 2016;128(12):1547-54.
11. DeLoughery T. Thrombocytopenia in Critical Care Patients. Journal of Intensive Care Medicine. 2002;17(6):267-282.
12. DeLoughery T, Liebler J, Simonds V y col. Invasive line placement in critically ill patients: do hemostatic defects matter? Transfusion. 1996;36:827-831.
13. Fondevila C, Goette N, Lavergne M y col. Trombocitopenia immune. Guías de diagnóstico y tratamiento. Sociedad Argentina de Hematología, 2019; 219-236.
14. Gómez N, Macías R y Pedroso I. El factor de activación plaquetaria y su relación con el daño oxidativo. Revista Cubana de Investigación Biomed. 2001;20(1):64-69.
15. Greinacher A, Selleng S. How I evaluate and treat thrombocytopenia in the intensive care unit patient. Blood Journal. 2016;128(26):3032-3042.
16. Holinstat M. Normal platelet function. Cancer Metastasis. 2017;36(2):195-198.
17. Hui P, Cook D, Lim W y col. The frequency and clinical significance of thrombocytopenia complicating critical illness. Chest Journal. 2011;139(2):271-278.
18. Koupenova M, Clancy L, Corkrey H y col. Circulating platelets as mediators of immunity, inflammation, and thrombosis. Circulation Research. 2018;122(2):337-351.
19. Lambert M, Gemsheimer T. Clinical updates in adult immune thrombocytopenia. . Blood Journal. 2017;129(21):2829-2835.
20. Marco C, Sánchez M, Hortiguela V y col. Trombocitopenia grave al ingreso en una unidad de cuidados intensivos en pacientes con disfunción orgánica. Med Intensiva. 2012;36 (3):185-192.
21. Muronoi T y col. Inmature platelet fraction predicts coagulopathy-related platelet consumption and mortality in patients with sepsis. Thrombosis Research. 2014;144:169-175.
22. Naime A, Ganaes J, Lopes M. Sepsis: the involvement of platelets and the current treatments. Current Molecular Pharmacology. 2018;11(4):261-269.
23. Ostadi Z, Shadvar K, Sanaie S y col. Thrombocytopenia in the intensive care unit. Pakistan Journal of Medical Sciences. 2019;35(1):282-287.
24. Quach M, Chen W, Li R. Mechanisms of platelet clearance and translation to improve platelet storage. Blood Journal. 2018;131(14):1512-1521.
25. Ramadan A, Wuescher L, Randall W. Platelets: essential components of the immune system. Current Trends in Immunology. 2015;16:65-78.
26. Riveros, D. El paciente trombocitopénico en la Unidad de Cuidados Intensivos. XIII Congreso del Grupo CAHT. 2018;22:30-36.
27. Secchim L, Migliari L, Franklin B. Regulation of Innate Immune Responses by Platelets. Frontiers in Immunology. 2019;10(Art. 1320):1-9.
28. Semple J, Freedman J. Platelets and innate immunity. Cellular and Molecular Life Sciences. 2010;67:499-511.
29. Sharathkumar A, Shapiro A. Trastornos de la función plaquetaria. Tratamiento de la Hemofilia. 2008;19:1-22.
30. Thachil J, Warkentin T. How do we approach thrombocytopenia in critically ill patients? British Journal of Haematology. 2017;177(1):27-38.
31. Van Den Bemt P, Meyboom R. Drug-Induced immune thrombocytopenia. Drug Safety. 2004;27 (15):1243-1252.
32. Wang H, Aguilera C, Knopf K y col. Thrombocytopenia in the Intensive Care Unit. J Intensive Care Med. 2013;28(5):268-280. 33. Williamson D, Albert M, Heels D. Thrombocytopenia in critically ill patients receiving thromboprophylaxis. Frequency, risk factors, and outcomes. CHEST Journal. 2013;144 (4):1207-1215.
34. Zarychanski R., Houston D. Assessing thrombocytopenia in the intensive care unit: The past, present, and future. Hematology. 2017;1:660-666.
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