First study on Factor V Leiden detection in Nicaraguan patients with unprovoked venous thromboembolism: Preliminary report
Vol. 22 No. 2 (2018), Brief communications
Vol. 22 No. 2 (2018)

First study on Factor V Leiden detection in Nicaraguan patients with unprovoked venous thromboembolism: Preliminary report

Brief communications
Published 2019-01-15
L Montealegre
Laboratorio de Biología Molecular “MA. Elmer Cisneros” in memoriam, Instituto Politécnico de la Salud, Universidad Nacional Autónoma de Nicaragua
W Ruiz
Laboratorio de Biología Molecular “MA. Elmer Cisneros” in memoriam, Instituto Politécnico de la Salud, Universidad Nacional Autónoma de Nicaragua
S Estrada
Hospital Escuela “Roberto Calderón”, Managua, Nicaragua
K García
Laboratorio de Biología Molecular “MA. Elmer Cisneros” in memoriam, Instituto Politécnico de la Salud, Universidad Nacional Autónoma de Nicaragua
C Santamaría
Laboratorio de Diagnóstico Molecular, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, San José, Costa Rica
A Puller
Laboratorio de Biología Molecular “MA. Elmer Cisneros” in memoriam, Instituto Politécnico de la Salud, Universidad Nacional Autónoma de Nicaragua
A Pernudy
Laboratorio de Biología Molecular “MA. Elmer Cisneros” in memoriam, Instituto Politécnico de la Salud, Universidad Nacional Autónoma de Nicaragua
ISSN 2250-8309 (versión en línea) - ISSN 0329-0379 (versión impresa)
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Keywords

factor V Leiden, genetic thrombophilia, venous thromboembolism

How to Cite

Montealegre, L., Ruiz, W., Estrada, S., García, K., Santamaría, C., Puller, A., & Pernudy, A. (2019). First study on Factor V Leiden detection in Nicaraguan patients with unprovoked venous thromboembolism: Preliminary report. Journal of Hematology, 22(2), 193–196. Retrieved from https://revistahematologia.com.ar/index.php/Revista/article/view/27
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Abstract

Factor V Leiden (FVL) is the most common genetic thrombophilia. It is constituted by the substitution of a guanine by an adenine in nucleotide 1691 of the gene coding for the coagulation factor V. As a result, the regulatory mechanisms of hemostasis are altered with predominance of procoagulant mechanisms. A cross-sectional study was carried out in 21 patients with a diagnosis of unprovoked vein thromboembolism. The processing of the biological samples was performed by polymerase chain reaction -  restriction fragment length polymorphism (PCR-RFLP). The FVL was detected in 14.3% of studied patients, all with heterozygous genotype. This preliminary report is the first study on Nicaraguan patients with venous thrombosis and the observed FVL frequency is comparable with previous reports from Latin America countries.

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