Stereotyped receptors in chronic lymphocytic leukemia. Frequency and distribution in Latin American countries
Vol. 22 No. 1 (2018), Original articles
Vol. 22 No. 1 (2018)

Stereotyped receptors in chronic lymphocytic leukemia. Frequency and distribution in Latin American countries

Original articles
Published 2019-04-16
C Stanganelli
División Patología Molecular, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina
N Sotelo
Instituto de Biotecnología, Universidad Nacional de Misiones, Misiones, Argentina
ME Márquez
Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela
J Cabrera
División Patología Molecular, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Buenos Aires, Argentina
PA Deglesne
Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela
JL López
Banco Municipal de Sangre, Caracas, Venezuela
R Bezares
Hospital Álvarez, Buenos Aires, Argentina
R Gabús
Hospital Maciel, Montevideo, Uruguay
P Oppezzo
Instituto Pasteur, Montevideo, Uruguay
I Slavutsky
Laboratorio de Genética de Neoplasias Linfoides, Instituto de Medicina Experimental, CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina
ISSN 2250-8309 (versión en línea) - ISSN 0329-0379 (versión impresa)
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Keywords

chronic lymphocytic leukemia, IGHV, stereotyped B-cell receptor.

How to Cite

Stanganelli, C., Sotelo, N., Márquez, M., Cabrera, J., Deglesne, P., López, J., Bezares, R., Gabús, R., Oppezzo, P., & Slavutsky, I. (2019). Stereotyped receptors in chronic lymphocytic leukemia. Frequency and distribution in Latin American countries. Journal of Hematology, 22(1), 13–20. Retrieved from https://revistahematologia.com.ar/index.php/Revista/article/view/106
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Abstract

The IGHV (immunoglobulin heavy chain variable region) gene mutational status is considered an important prognostic factor in chronic lymphocytic leukemia (CLL). We have evaluated the presence of IGHV mutational status, gene usage and stereotyped B-cell receptors (BCRSs) in CLL patients from a multicenter study developed in the context of the Latin American Group of CLL (LAG-CLL). Our cohort included 431 unselected CLL patients from Argentina (253), Uruguay (99) and Venezuela (79). Analysis of data showed over-representation of mutated cases. Concerning IGHV family usage, VH3>VH4>VH1 distribution was found in Argentina, while VH3>VH1>VH4 was observed in the other countries. The most frequently used IGHV genes were IGHV1-69, IGHV3-23 and IGHV4-34. IGHV3-21 was present in 10% of Venezuelan patients but showed lower frequencies in the Uruguayan (2%) cohort and intermediate frequency in the Argentinean series (6.7%). BCRSs were observed in 15.2% of total cases. Two novel potential subsets were detected. IGHV3-21 gene was always included in the heterogeneous group in Venezuelan cohorts. Argentinean series exhibit over-representation of cluster #2 (3.13%), while Uruguay showed the highest frequency of cluster #4 (4.04%). Venezuelan CLL patients showed very low percentages of major clusters (5.1%). These results are the first integrated IGHV analysis from Latin American countries. They showed interesting differences, reflecting variations in the genetic background and/or differences in environmental factors operating in CLL pathogenesis in this particular geographic area.

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